Wednesday, March 09, 2011
supplement companies are focused on bringing B12 rich dietary formulas
to their consumers, but can this vitamin truly help to achieve the
desired benefits? Like boosting energy, losing weight? And if so, how
would it work.
B12 levels are necessary for the proper functioning of the body. It is
absolutely necessary in the formation of new tissues and protecting the
DNA, but it also may have some influence on one’s overall metabolism
rates. Especially if the individual is experiencing general issues with
absorption in the stomach, as is common with B12 deficiency.
a study involving 15,655 participants between the ages of 53 to 57
years, long-term (10-year) use of multivitamins, vitamins B6 and B12,
and chromium, were found to be significantly associated with lower
levels of weight gain (1). Lack of all the
needed vitamins and minerals will cause the system to slow down when it
comes to metabolism. This is the body’s way of assuring its own
survival. Vitamin B12 is can be an energy booster, and in properly
administered amounts it results in the body having healthy,
long-lasting energy. This of course will not take off the pounds by
itself, but the extra energy stores replacing the feeling of fatigue is
often a great motivator to get up and move, resulting in weight loss.
B12 and other health conditions
Alzheimer's disease and dementia
with Alzheimer's disease often have low blood levels of vitamin B12.
One study found lower vitamin B12 levels in the cerebrospinal fluid of
patients with Alzheimer's disease than in patients with other types of
dementia, though blood levels of vitamin B12 did not differ (2). In
another study, low serum vitamin B12 (= 150 pmol/L) or folate (= 10
nmol/L) levels were associated with a doubling of the risk of
developing Alzheimer's disease in 370 elderly men and women followed
over three years (3). In a sample of 1,092 men and women without
dementia followed for an average of ten years, those with higher plasma
homocysteine levels at baseline had a significantly higher risk of
developing Alzheimer's disease and other types of dementia (4)
studies have found as many as 30% of patients hospitalized for
depression are deficient in vitamin B12 (5). A cross-sectional study of
700 community-living, physically disabled women over the age of 65
found that vitamin B12 deficient women were twice as likely to be
severely depressed as non-deficient women (6). A population-based study
in 3,884 elderly men and women with depressive disorders found that
those with vitamin B12 deficiency were almost 70% more likely to
experience depression than those with normal vitamin B12 status (7).
is required for synthesis of DNA, and there is evidence that decreased
availability of folate results in strands of DNA that are more
susceptible to damage. Deficiency of vitamin B12 traps folate in a form
that is unusable by the body for DNA synthesis. Both vitamin B12 and
folate deficiencies result in a diminished capacity for methylation
reactions. Thus, vitamin B12 deficiency may lead to an elevated rate of
DNA damage and altered methylation of DNA, both of which are important
risk factors for cancer. In a double-blind, placebo-controlled study,
the same biomarker of chromosome breakage was minimized in young adults
who were supplemented with 700 mcg of folic acid and 7 mcg of vitamin
B12 daily in cereal for two months (8).
more information about vitamin B 12 injections, please contact Dr. Lee
via email email@example.com or 206-319-5322. Don’t
forget to ask about B12 happy hour where B12 injections are only $12. Learn more about naturopathic care at Seattle Naturopathic Center.
supplements and weight control in a middle-age population," Nachtigal
MC, Patterson RE, et al, J Altern Complement Med., 2005; 11(5): 909-15.
Nourhashemi F, Gillette-Guyonnet S, Andrieu S, et al. Alzheimer
disease: protective factors. Am J Clin Nutr. 2000;71(2):643S-649S.
Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate,
vitamin B12, and serum total homocysteine levels in confirmed Alzheimer
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Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L.
Vitamin B(12) and folate in relation to the development of Alzheimer's
disease. Neurology. 2001;56(9):1188-1194.
5. Hutto BR. Folate and cobalamin in psychiatric illness. Compr Psychiatry. 1997;38(6):305-314.
Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP.
Vitamin B(12) deficiency and depression in physically disabled older
women: epidemiologic evidence from the Women's Health and Aging Study.
Am J Psychiatry. 2000;157(5):715-721.
Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM.
Vitamin B12, folate, and homocysteine in depression: the Rotterdam
Study. Am J Psychiatry. 2002;159(12):2099-2101.
Fenech M. Micronucleus frequency in human lymphocytes is related to
plasma vitamin B12 and homocysteine. Mutat Res. 1999;428(1-2):299-304.